2,4-dioxo-3-azaspiro[5.5]undecane-1,5-dicarbonitrile
- CasNo:4355-15-1
Product Description
High Quality Chinese Manufacturer supply 4355-15-1 2,4-dioxo-3-azaspiro[5.5]undecane-1,5-dicarbonitrile
- Molecular Formula: C12H13 N3 O2
- Molecular Weight: 231.254
- Vapor Pressure: 1.95E-12mmHg at 25°C
- Boiling Point: 556.9°Cat760mmHg
- Flash Point: 290.6°C
- PSA： 93.75000
- Density: 1.28g/cm3
- LogP: 1.20166
2,4-dioxo-3-azaspiro[5.5]undecane-1,5-dicarbonitrile(Cas 4355-15-1) Usage
InChI:InChI=1/C12H13N3O2/c13-6-8-10(16)15-11(17)9(7-14)12(8)4-2-1-3-5-12/h8-9H,1-5H2,(H,15,16,17)
4355-15-1 Relevant articles
A 2, 4 - dioxo -3 - aza spiro - [5, 5] undecane - 1, 5 - dinitrile preparation method (by machine translation)
-
Paragraph 0009; 0035; 0036; 0038; 0040; 0041; 0043; 0045, (2019/03/08)
The present invention provides a 2, 4 - ...
Process for the preparation of gabapentin hydrochloride
-
Page/Page column 3-4, (2009/04/24)
A process for preparation of gabapentin ...
Synthesis of 4-substituted 3,5-dicyano-2,6-piperidinediones using lithium nitride as a convenient source of ammonia
Wu, Liqiang,Yang, Chunguang,Yang, Liming,Yang, Lijuan
experimental part, p. 977 - 982 (2009/09/30)
A simple and efficient one-pot synthesis...
PROCESS FOR THE PREPARATION OF GABAPENTIN HYDROCHLORIDE
-
Page/Page column 5; 6, (2008/12/06)
A process for preparation of gabapentin ...
4355-15-1 Process route
-
-
C12 H13 N3 O2 *H3 N
-
![2,4-dioxo-3-azaspiro[5.5]undecane-1,5-dicarbonitrile](/upload/2026/3/8929262aac474896bb874689970cb411_1ab3c179-87f2-4627-a1f8-d316590ec8c6.png)
-
4355-15-1
2,4-dioxo-3-azaspiro[5.5]undecane-1,5-dicarbonitrile
| Conditions | Yield |
|---|---|
|
With
sulfuric acid;
In
water;
at 70 ℃;
for 2h;
pH=1.2;
pH-value;
Temperature;
Industrial scale;
|
98.94%
|
-
-
108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone
-
-
105-56-6
ethyl 2-cyanoacetate
-
-
4355-15-1
2,4-dioxo-3-azaspiro[5.5]undecane-1,5-dicarbonitrile
| Conditions | Yield |
|---|---|
|
With
ammonia;
In
methanol; water;
at -5 - 25 ℃;
for 48h;
Product distribution / selectivity;
|
85%
|
|
cyclohexanone; ethyl 2-cyanoacetate;
With
ammonia;
In
methanol; water;
at -5 - 60 ℃;
for 48h;
With
sulfuric acid;
In
methanol; water;
at 5 - 60 ℃;
pH=2 - 3;
Product distribution / selectivity;
|
85%
|
|
With
methanol; lithium nitride;
at 20 ℃;
for 14h;
sealed;
|
83%
|
|
With
ammonia;
|
|
|
With
ammonia;
In
ethanol;
|
|
|
With
ammonia;
In
ethanol; water;
at 5 - 25 ℃;
for 48h;
Product distribution / selectivity;
|
|
|
cyclohexanone; ethyl 2-cyanoacetate;
With
ammonia;
In
ethanol; water;
at 5 - 60 ℃;
for 48h;
With
sulfuric acid;
In
ethanol; water;
at 5 - 60 ℃;
pH=2 - 3;
Product distribution / selectivity;
|
4355-15-1 Upstream products
-
108-94-1
cyclohexanone
-
105-56-6
ethyl 2-cyanoacetate
-
107-91-5
cyanoacetic acid amide
-
6802-76-2
ethyl 2-cyano-2-cyclohexylideneacetate
4355-15-1 Downstream products
-
4355-11-7
1,1-cyclohexanediacetic acid
-
60142-96-3
H-Gpn-OH
-
108667-25-0
cyclohexylidenedi-acetic acid diethyl ester
-
3187-27-7
2,2'-(cyclohexane-1,1-diyl)bis(ethan-1-ol)