N'-Nitro-L-arginine-methyl ester hydrochloride
- CasNo:51298-62-5
Product Description
Manufacturer supply top purity N'-Nitro-L-arginine-methyl ester hydrochloride 51298-62-5 with ISO standards
- Molecular Formula:C7H16ClN5O4
- Molecular Weight:269.688
- Appearance/Colour:white to off-white powder
- Vapor Pressure:3.83E-07mmHg at 25°C
- Melting Point:157-161 °C
- Refractive Index:15 ° (C=3, MeOH)
- Boiling Point:383.5 °C at 760 mmHg
- Flash Point:185.8 °C
- PSA：146.05000
- LogP:1.47960
N'-Nitro-L-arginine-methyl ester hydrochloride(Cas 51298-62-5) Usage
|
Biochem/physiol Actions |
Primary TargeteNOS |
|
Definition |
ChEBI: A hydrochloride obtained by combining Ngamma-nitro-L-arginine methyl ester with one equivalent of hydrochloric acid. |
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General Description |
More soluble analog of arginine and a competitive, slowly reversible inhibitor of endothelial nitric oxide synthase (IC50 = 500 nM). Causes a prolonged inhibition of acetylcholine-induced relaxation of rat aortic rings (IC50 = 400 nM). |
InChI:InChI=1/C7H15N5O4.ClH/c1-16-6(13)5(8)3-2-4-10-7(9)11-12(14)15;/h5H,2-4,8H2,1H3,(H3,9,10,11);1H
51298-62-5 Relevant articles
Novel L-arginine derivatives as aminopeptidase N inhibitors: design, chemistry, and pharmacological evaluation
Mou, Jiajia,Luan, Yepeng,Chen, Danghui,Wang, Qiang
, p. 3015 - 3025 (2017/10/06)
Considering the important roles played i...
A class of novel Schiff's bases: Synthesis, therapeutic action for chronic pain, anti-inflammation and 3D QSAR analysis
Zhou, Yinjian,Zhao, Ming,Wu, Yingting,Li, Chunyu,Wu, Jianhui,Zheng, Meiqing,Peng, Li,Peng, Shiqi
experimental part, p. 2165 - 2172 (2010/05/18)
To discover analgesics for treating chro...
Design, synthesis and primary activity assay of bi- or tri-peptide analogues with the scaffold l-arginine as amino-peptidase N/CD13 inhibitors
Mou, Jiajia,Fang, Hao,Liu, Yingzi,Shang, Luqing,Wang, Qiang,Zhang, Lei,Xu, Wenfang
scheme or table, p. 887 - 895 (2010/05/02)
A series of bi- or tri-peptide analogues...
Design, synthesis and primary activity evaluation of l-arginine derivatives as amino-peptidase N/CD13 inhibitors
Mou, Jiajia,Fang, Hao,Jing, Fanbo,Wang, Qiang,Liu, Yingzi,Zhu, Huawei,Shang, Luqing,Wang, Xuejian,Xu, Wenfang
scheme or table, p. 4666 - 4673 (2009/12/01)
A series of l-arginine derivatives were ...
51298-62-5 Process route
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-
112208-06-7
Nα-(tert-butoxycarbonyl)-NG-nitro-L-arginine methyl ester
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50903-99-6,141968-19-6,51298-62-5,126265-24-5
L-NAME
| Conditions | Yield |
|---|---|
|
With
trifluoroacetic acid;
In
dichloromethane;
|
-
-
67-56-1
methanol
-
-
2149-70-4,13855-78-2,38733-00-5
N-nitro-L-arginine
-
-
50903-99-6,141968-19-6,51298-62-5,126265-24-5
L-NAME
| Conditions | Yield |
|---|---|
|
With
thionyl chloride;
at 0 - 20 ℃;
|
90% |
|
With
thionyl chloride;
|
51298-62-5 Upstream products
-
67-56-1
methanol
-
2149-70-4
N-nitro-L-arginine
-
1119-34-2
L-arginine hydrochloride
-
2188-18-3
Boc-Arg(NO2)-OH
51298-62-5 Downstream products
-
106386-19-0
Nα-(N2,N6-bis-benzyloxycarbonyl-L-lysyl)-Nω-nitro-L-arginine methyl ester
-
66345-00-4
C18H26N6O7
-
23734-44-3
Cbo-L-Val-nitro-L-Arg-methylester
-
106655-93-0
