5,7-Diiodo-8-quinolinol
- CasNo:83-73-8
Product Description
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1.What is the 5,7-Diiodo-8-quinolinol ?
5,7-Diiodo-8-quinolinol, also known as Iodoquinol, is a synthetic antiprotozoal drug with amebicidal properties. It is effective against both cysts and trophozoites of the E. histolytica parasite, which is responsible for causing amebiasis. The exact mechanism of action is not well understood, but it is considered the drug of choice for treating asymptomatic or moderate forms of the disease.
Iodoquinol (diiodohydroxyquin, Yodoxin, Moebiquin) is a halogenated 8-hydroxyquinoline derivative whose precise mechanism of action is not known but is thought to involve an inactivation of essential parasite enzymes. Iodoquinol kills the trophozoite forms of E. histolytica, B. coli, B. hominis, and Dientamoeba fragilis. Iodoquinol is absorbed from the gastrointestinal tract and is excreted in the urine as glucuronide and sulfate conjugates. Most of an orally administered dose is excreted in the feces. Iodoquinol has a plasma half-life of about 12 hours. Iodoquinol is the drug of choice in the treatment of asymptomatic amebiasis and D. fragilis infections. It is also used in combination with other drugs in the treatment of other forms of amebiasis and as an alternative to tetracycline in the treatment of balantidiasis. Adverse reactions are related to the iodine content of the drug; the toxicity is often expressed as skin reactions, thyroid enlargement, and interference with thyroid function studies. Headache and diarrhea also occur. Chronic use of clioquinol, a closely related agent, has been linked to a myelitislike illness and to optic atrophy with permanent loss of vision.
It acts as an amoebicidal and so used in the treatment of amoebiasis, balantidiasis (an infection caused by protozoa).
2.What is the CAS number for 5,7-Diiodo-8-quinolinol ?
The CAS number of 5,7-Diiodo-8-quinolinol is 83-73-8.
More information of 5,7-Diiodo-8-quinolinol 83-73-8 are:
|
CAS?Number |
83-73-8 |
|
Density |
2.491 g/cm3 |
|
Melting Point |
>200 °C (dec.)(lit.) |
|
Boiling Point |
401.8 °C at 760 mmHg |
|
Flash Point |
196.8 °C |
|
Vapor Pressure |
4.96E-07mmHg at 25°C |
|
Refractive Index |
1.828 |
|
HS CODE |
29334900 |
|
PSA |
33.12000 |
|
LogP |
3.14960 |
|
Pka |
pKa 8.0 (Uncertain) |
3.What is the molecular formula of 5,7-Diiodo-8-quinolinol ?
The chemical formula of?5,7-Diiodo-8-quinolinol is C9H5I2NO which containing 9 Carbon atoms,5 Hydrogen atoms,2 Iodine atoms,1 Nitrogen atoms and 1 Oxygen atoms,and the molecular weight, and the molecular weight of 5,7-Diiodo-8-quinolinol is 396.954
4.What is 5,7-Diiodo-8-quinolinol(83-73-8)used for?
5,7-Diiodo-8-quinolinol, also known as Iodoquinol, is a synthetic antiprotozoal drug with amebicidal properties. It is effective against both cysts and trophozoites of the E. histolytica parasite, which is responsible for causing amebiasis. The exact mechanism of action is not well understood, but it is considered the drug of choice for treating asymptomatic or moderate forms of the disease.
InChI:InChI=1/C9H5I2NO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H
Relevant articles related to 5,7-Diiodo-8-quinolinol:
|
Article |
Source |
|
- |
Papesch,Burtner , p. 1314 (1936) |
|
Iodination of industrially important aromatic compounds with aqueous potassium triiodide |
Sharma,Srivastava,Agarwal,Diwedi , p. 433 - 436 (2016/06/13) |
5.Buy high quality and low price 5,7-Diiodo-8-quinolinol 83-73-8 now
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