(+)-5-Iodo-2'-deoxyuridine
- CasNo:54-42-2
Product Description
Quality products?make an important contribution to long-term revenue and profitability. Cost-effective customized wholesale (+)-5-Iodo-2'-deoxyuridine 54-42-2
1.What is the (+)-5-Iodo-2'-deoxyuridine ?
Idoxuridine (Herplex) is a water-soluble iodinated derivative of deoxyuridine that inhibits several DNA viruses including HSV, VZV, vaccinia, and polyoma virus. The triphosphorylated metabolite of idoxuridine inhibits both viral and cellular DNA synthesis and is also incorporated into DNA. Such modified DNA is susceptible to strand breakage and causes aberrant viral protein synthesis. Because of its significant host cytotoxicity, idoxuridine cannot be used to treat systemic viral infections. The development of resistance to this drug is common.
A cytotoxic analog of thymidine, antiviral
-
-
951-78-0,63844-76-8
2'-deoxyuridine
-
-
54-42-2,162239-35-2
5-Iodo-2'-deoxyuridine
| Conditions | Yield |
|---|---|
|
With
iodine; silver nitrate;
In
methanol;
at 40 ℃;
for 3h;
|
100%
|
|
With
iodine; silver nitrate;
In
methanol;
at 40 ℃;
for 3h;
|
100%
|
|
With
sodium azide; Iodine monochloride;
In
acetonitrile;
at 25 ℃;
for 24h;
Product distribution;
Mechanism;
other uracil nucleosides; other halogenation agents; var. temp. and time;
|
96%
|
|
With
sodium azide; Iodine monochloride;
In
acetonitrile;
at 25 ℃;
for 24h;
|
96%
|
|
With
1-(2-methoxyethyl)-3-methylimidazolium trifluoroacetate; N-iodo-succinimide;
at 60 ℃;
for 0.0666667h;
|
89%
|
|
With
ammonium cerium (IV) nitrate; 1-ethylene glycol monomethyl ether-3-methylimidazolium methanesulfonate; lithium iodide;
at 80 ℃;
for 0.166667h;
|
82%
|
|
With
ammonium cerium (IV) nitrate; iodine;
In
acetonitrile;
at 50 ℃;
for 4h;
|
81%
|
|
With
ammonium cerium(IV) nitrate; lithium iodide;
In
methanol;
at 80 ℃;
|
77%
|
|
With
Iodine monochloride;
In
methanol;
at 50 ℃;
for 1.5h;
|
76%
|
|
With
iodine;
In
acetonitrile;
Ambient temperature;
electrolysis (Pt electrodes, Ag/Ag+ reference, LiClO4 as supporting electrolyte);
|
75%
|
|
With
iodine; silver sulfate;
In
methanol;
for 0.2h;
Ambient temperature;
|
71%
|
|
With
iodine; nitric acid;
|
|
|
With
Iodine monochloride; triethylamine;
Yield given. Multistep reaction;
1.) MeOH, 30 min, 2.) 1 h;
|
|
|
With
iodic acid;
|
-
-
951-78-0,63844-76-8
2'-deoxyuridine
-
-
696-07-1
5-iodouracil
-
-
54-42-2,162239-35-2
5-Iodo-2'-deoxyuridine
-
-
66-22-8,144104-68-7,18324-22-6,27072-01-1,2920-92-5,51953-19-6
uracil
| Conditions | Yield |
|---|---|
|
With
thymidine phosphorylase from Escherichia coli (E.C. 2.4.2.4) immobilized on Sepabeads EC-EP;
In
aq. phosphate buffer;
at 20 ℃;
for 3h;
pH=7.5;
Reagent/catalyst;
Enzymatic reaction;
|
2.What is the CAS number for (+)-5-Iodo-2'-deoxyuridine ?
The CAS number of (+)-5-Iodo-2'-deoxyuridine is 54-42-2.
More information of (+)-5-Iodo-2'-deoxyuridine 54-42-2 are:
|
CAS?Number |
54-42-2 |
|
Density |
2.148 g/cm3 |
|
Melting Point |
194 °C(lit.) |
|
Refractive Index |
30 ° (C=1, 1mol/L NaOH) |
|
HS CODE |
29389090 |
|
PSA |
104.55000 |
|
LogP |
-1.21810 |
|
Pka |
8.25(at 25℃) |
3.What are another words for (+)-5-Iodo-2'-deoxyuridine ?
Synonyms?for?(+)-5-Iodo-2'-deoxyuridine 54-42-2:1-(2-Deoxy-b-D-ribofuranosyl)-5-iodouracil;2'-Deoxy-5-iodouridine;5-Iodo-2'-deoxyuridine;5-Iodo-2'-desoxyuridine;5-Iododeoxyuridine;5-Iodouracil deoxyriboside;5IUDR;Allergan 211;Dendrid;Emanil;Herpe-Gel;Herpesil;Herpidu;Herplex;IDU;IDUR;IUDR;Idexur;Idoxene;Idoxuridin;Idoxuridine;Idu Oculos;Iducher;Idulea;Iduridin;Iododeoxyuridine;Joddeoxiuridin;Kerecid;NSC 39661;Ophthalmadine;SKF 14287;Stoxil;Stoxip;Synmiol;Virudox;
4.What is the molecular formula of (+)-5-Iodo-2'-deoxyuridine?
The chemical formula of ?(+)-5-Iodo-2'-deoxyuridine is?C9H11IN2O5 which containing 9 Carbon atoms,11 Hydrogen atoms,1 Iodine atoms,2 Nitrogen atoms and 5 Oxygen atoms,and the molecular weight of??(+)-5-Iodo-2'-deoxyuridine?is 354.101.
5.What is (+)-5-Iodo-2'-deoxyuridine (54-42-2) used for?
5-Iodo-2'-deoxyuridine is a nucleoside analog that inhibits the replication of viruses and other DNA-containing organisms. 2'-Deoxy-5-iodouridine also has inhibitory properties on cell nuclei, which may be due to its ability to bind with DNA and prevent the synthesis of RNA or protein.
Relevant articles related to (+)-5-Iodo-2'-deoxyuridine:
|
Article |
Source |
|
Thermodynamic Reaction Control of Nucleoside Phosphorolysis |
Kaspar, Felix,Giessmann, Robert T.,Neubauer, Peter,Wagner, Anke,Gimpel, Matthias supporting information, p. 867 - 876 (2020/01/24) |
|
Bio-catalytic synthesis of unnatural nucleosides possessing a large functional group such as a fluorescent molecule by purine nucleoside phosphorylase |
Hatano, Akihiko,Wakana, Hiroyuki,Terado, Nanae,Kojima, Aoi,Nishioka, Chisato,Iizuka, Yu,Imaizumi, Takuya,Uehara, Sanae , p. 5122 - 5129 (2019/10/05) |
6.Buy (+)-5-Iodo-2'-deoxyuridine with the best price .
Changzhou Wujin Qianhuang Sanyou Chemical Factory is a quality supplier of (+)-5-Iodo-2'-deoxyuridine. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on (+)-5-Iodo-2'-deoxyuridine 54-42-2.